Introduction to microdosing psilocybin – Alchimia weblog


After our introductory article on psilocybin and its results, we wish to current you with a short however full information on easy methods to microdose your favorite magic mushrooms. On this event, we’ve contacted Ana, a scientific psychologist and psychopharmacology and immunology specialist that has written this improbable article on microdosing psilocybin for the remedy of assorted ailments.

Right here you’ve this attention-grabbing textual content!

Microdosing psilocybin is changing into more and more fashionable

Information to microdosing psilocybin

Content material:

What’s in hallucinogenic mushrooms?

Mushrooms with hallucinogenic properties include two psychoactive alkaloids: psilocybin (4-phosphoryloxy-N, N-dimethyltryptamine) and psilocin (4-hydroxy-N, N-dimethyltryptamine). These chemical compounds are discovered in several species of fungi, like these belonging to the genus Psilocybe, Panaeolus and Copelandia, and likewise in “magic truffles“, that are compact plenty of mycelium.

When ingesting these mushrooms, the psilocybin is metabolized and reworked into psilocin, the substance accountable for the psychoactive results induced by this kind of fungi. Mushrooms additionally include different compounds resembling baeocystin and norbaeocystin. These compounds are believed to modulate the mushrooms normal motion, as they don’t appear to have any psychoactive results of their very own. They probably are accountable for the distinctive impact profile of every mushroom pressure, regardless that they include related doses of psilocybin and psilocin (1).

What’s Psilocybin and what are its results?

What’s microdosing?

The microdosing phenomenon, that’s, the common consumption of sub-perceptual quantities of psychedelics, like LSD or psilocybin mushrooms, has skilled an enormous recognition explosion lately, for the reason that publication of James Fadinam’s “The Psychedelic Explorer’s Information” in 2011. Microdosing will not be taking a low dose of a psychedelic and expertise the psychoactive results of the substance in a gentle manner. Quite the opposite, microdosing consists within the ingestion of sub-psychoactive or sub-perceptual portions of a psychedelic, the place its results shall be very delicate or fall beneath the perceptual degree, in order that you received´t expertise any of the everyday visible or perceptual modifications induced by a psychedelic substance.

A microdose is between 1/10 and 1/20 of a hallucinogenic dose. Microdosing is often built-in in your every day routine a number of instances per week, with a view to get hold of the potential bodily and psychological advantages of the substance with out experiencing a state of altered consciousness. From the viewpoint of a microdoser, it could be one thing like this: “I really feel productive, capable of concentrate on what I select to do, I get pleasure from my relationships, I’ve vitality, and I don’t bear in mind taking something” (2).

What are psilocybin microdoses used for?

Analysis on microdosing continues to be in its infancy. Actually, at the moment, there aren´t any severe randomized placebo-controlled trials. The data we’ve comes from surveys and evaluation of hundreds of microdosers all through the world. Some on-line boards on microdosing have greater than 40.000 subscribers. These customers’ stories counsel that mushrooms microdoses can improve creativity, cut back migraines and cluster complications, relieve gentle melancholy, nervousness and ache, and enhance focus.

A latest investigation on the consequences of microdoses of “magic truffles” means that this follow could enhance cognitive flexibility and the power to resolve issues. In line with the authors of the research, the microdosing of psilocybin mushrooms might be investigated within the close to future to assist individuals who endure from inflexible thought or behaviour patterns resembling these with melancholy or Obsessive-Compulsive Dysfunction (OCD).

Can depression be treated with microdoses of psilocybin?

Can melancholy be handled with microdoses of psilocybin?

A latest exploratory evaluation has linked mushrooms microdoses with enhancements in temper, and with a lower in damaging emotionality and dysfunctional attitudes (nervousness, rumination, depressed moods). The evaluation additionally mentions an enchancment in focus and the power to pay attention, interpersonal relations and social nervousness, and an improve of self-awareness and the power to meditate.

Nonetheless, the customers’ experiences might be mistaken for the placebo impact, as the themes know they’ve acquired a substance and due to this fact have sure expectations, or no less than the hope that stated substance will work. As well as, not all customers of microdoses appear to acquire the identical advantages; some are reporting elevated irritability, nervousness, and confusion, poor reminiscence, and fatigue.

There’s a latest research with animals which is the primary to reveal that microdosing produces helpful results on the temper and nervousness in rats with experimentally induced post-traumatic stress dysfunction. This research used microdoses of dimethyltryptamine (DMT), a compound from the tryptamines household with hallucinogenic properties discovered within the Amazonian brew Ayahuasca, whose molecules have a really related construction to these of psilocybin. The restrictions lie in whether or not these findings could be extrapolated to people.

Present scientific investigation on psychedelic psychotherapy has proven the therapeutic potential of full doses of psilocybin to alleviate treatment-resistant melancholy, OCD, alcohol and tobacco habit, and nervousness in terminally unwell sufferers. Future research ought to decide if microdosing psilocybin can supply the identical advantages as a complete journey, and which protocols and microdoses can be most applicable.

Learn how to put together and use microdoses of mushrooms

It is very important word that contemporary and dried mushrooms include totally different quantities of lively ideas. Psilocin is a extremely unstable molecule that begins degrading when it comes into contact with gentle or the oxygen within the air. Because of this, contemporary mushrooms are stronger, as they include each psilocybin and psilocin, whereas dry mushrooms are much less potent as a result of their psilocin has been degraded.

Fresh Psilocybe mushrooms

Recent Psilocybe mushrooms

The lively ideas are additionally discovered in several quantities relying on the kind of pressure, the best way it’s been grown and dried, and its measurement; and even the totally different elements of the mushroom (stem, cap) can include varied quantities of alkaloids. Due to this fact, it’s endorsed to dry and grind the mushrooms. When grinding the mushrooms, the totally different alkaloid content material within the caps and the stems balances itself, in addition to the totally different sizes of the mushrooms.

One microdose of Psilocybe cubensis consists of 0.1-0.5 grams of dry mushrooms. If you’ll use microdoses of psilocybin truffles, you’ve to remember that dry truffles typically include much less psilocybin than dried mushrooms. You should utilize between 0.5 and 1 gram of dry powdered truffles per microdose. It isn’t advisable to swap the mushrooms varieties through the microdose protocol, as this is able to complicate the calibration of the dose when ingesting various quantities of the psychoactive substance for every pressure. An excellent method is to decide on one pressure to start out with, and preserve the protocol with the identical pressure till its completion.

You can begin by weighing round 0.1g of powder on a precision scale and use it as an preliminary microdose. After which modify the quantity in response to the consequences of this primary dose. Microdosing daily will not be really useful. Traditional psychedelics resembling psilocybin produce tolerance, so it’s doable to really feel fewer results after just a few days. Because of this, James Fadiman, writer of “The Psychedelic Explorer´s Information”, suggests ready a few days between every microdose.

This manner, you’ll be taking a microdose on day 1, not have any on days 2 and three, and take one once more on day 4. This course of continues for a number of weeks, taking every day notes in a journal, together with the times between takes, and recording the consequences within the precise second, and short-term and long-term modifications in temper, vitality, and behavior.

Ideally, you can begin on a time without work, with a view to observe the consequences and have the ability to modify the dose with out an excessive amount of social interplay. The microdosing protocol ought to be included into your every day routine, which implies that you´ll know you’re taking larger doses for those who expertise psychoactive results. Additionally, the microdosing quantities could be greater or decrease relying on the neurophysiology of every particular person, and an essential a part of the method is to seek out the right dose for every case. This course of can contain a number of makes an attempt, so it´s higher to start out from the underside till you discover your perfect psilocybin microdose.

Once harvested and dried, mushrooms can be easily dosed

As soon as harvested and dried, mushrooms could be simply dosed

Is psilocybin microdosing protected?

In line with all kinds of toxicological research and scientific trials, psilocybin has very low toxicity. Traditional hallucinogens resembling psilocybin work together primarily with the serotonin receptor 5-HT2A, which is accountable for the psychedelic results. Provided that persistent psychedelic consumption reduces the variety of 5-HT2A receptors, which ends up in a fast and transient tolerance, the chance of habit to hallucinogens, psilocybin included, may be very low. As well as, psilocybin doesn’t straight have an effect on the mesolimbic dopaminergic pathway, and due to this fact doesn’t activate the reward system.

One more reason why you shouldn´t take microdoses every day is that there’s a hypothetical danger, of which we nonetheless haven´t collected sufficient knowledge, that might have an effect on the coronary heart valve of an individual who makes use of psychedelics continuously. Traditional psychedelics additionally work together with different receptors resembling 5-HT2B, that are additionally discovered within the coronary heart. Though psilocybin has a really low binding potential with this receptor (Ki = 4.6 nM), we nonetheless don´t have sufficient knowledge to rule out this hypothetical antagonistic impact, and as a precautionary measure, and though it´s not recognized how this danger its mirrored on the subject of microdosing, it’s best to keep away from microdosing too typically or for quite a lot of months per 12 months.

Microdoses of psilocybin, or different mind-altering medicine, can have potential dangers for individuals with psychological diseases resembling bipolar dysfunction or schizophrenia.
To see the potential interactions between microdoses and medicines, you’ll be able to seek the advice of James Fadiman´s web site.


Ana Elda Maqueda

Medical psychologist and psychopharmacology and immunology specialist


  • José Carlos Bouso Saiz, a number of authors. Psilocibes. Editorial: Ultrarradio / ICEERS
  • James Fadiman & Sophia Korb (2019). Would possibly Microdosing Psychedelics Be Secure and Useful? An Preliminary Exploration Journal of Psychoactive Medication, DOI: 10.1080/02791072.2019.1593561


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